{"id":955,"date":"2024-07-16T10:21:52","date_gmt":"2024-07-16T02:21:52","guid":{"rendered":"https:\/\/collagensei.com\/?p=955"},"modified":"2024-08-05T15:36:46","modified_gmt":"2024-08-05T07:36:46","slug":"keratin","status":"publish","type":"post","link":"https:\/\/collagensei.com\/tr\/keratin\/","title":{"rendered":"Keratin"},"content":{"rendered":"

<\/p>\n

\u25baKeratin nedir?<\/strong><\/span><\/p>\n

Keratin<\/a>\u00a0lifli bir yap\u0131sal proteindir ve sa\u00e7lar\u0131, boynuzlar\u0131, pen\u00e7eleri ve insan derisinin d\u0131\u015f tabakas\u0131n\u0131 olu\u015fturan ana proteindir. Keratin epitel h\u00fccrelerini hasar veya bas\u0131n\u00e7tan koruyabilir. Keratin monomerleri, ara fibr\u00f6z proteinler (ara protein, IP) olu\u015fturmak i\u00e7in demetler olu\u015fturur<\/span>
\nKeratin peptit zincirleri, y\u00fcksek oranda korunmu\u015f \u00e7ubuk benzeri ara ve telopeptit b\u00f6lgelerine b\u00f6l\u00fcnm\u00fc\u015f \u00e7oklu yap\u0131sal alan zincirleridir. \u00c7ubuk benzeri yap\u0131sal alanlar\u0131n peptit zinciri, 8 peptit tekrar\u0131ndan olu\u015fan periyodik bir dizi yap\u0131s\u0131nda bulunur. T\u00fcm ara fibriller yumurtalar benzer bir peptit zinciri konfig\u00fcrasyonuna sahiptir. Keratin peptit zincirleri tipik olarak alfa helikslerdir. Asidik ve bazik keratin peptit zincirleri, keratinin karakteristik konformasyonel formu olan heteromerik kompleks heliksler olu\u015fturmak \u00fczere birle\u015fir.<\/span>
\nSa\u00e7 keratinleri ve epidermal keratinlerin farkl\u0131 keratin peptit zincirlerinden olu\u015fmas\u0131yla birlikte, \u015fimdiye kadar 20'den fazla keratin peptit t\u00fcr\u00fc ke\u015ffedilmi\u015ftir. Keratin y\u00fcksek oranda sistein i\u00e7erir ve sisteinin \u00e7apraz ba\u011flanmas\u0131 keratindeki ana \u00e7apraz ba\u011flanma yap\u0131s\u0131d\u0131r. Keratinin fiziksel ve kimyasal \u00f6zellikleri temel olarak bu \u00e7apraz ba\u011flanma yap\u0131s\u0131yla ilgilidir.<\/span><\/p>\n

\u25ba\u00d6zellikler ve Yap\u0131<\/strong><\/span><\/p>\n

Suda, tuz \u00e7\u00f6zeltilerinde, seyreltik asitlerde veya seyreltik bazlarda \u00e7\u00f6z\u00fcnmez. Keratin, ektodermden farkl\u0131la\u015fan h\u00fccrelerden t\u00fcretilir ve bu h\u00fccrelerdeki yap\u0131sal proteinlerden biridir. Bu nedenle keratin sa\u00e7, k\u0131l, pul, t\u00fcy, t\u0131rnak, toynak, boynuz, pen\u00e7e, gaga, filament ve di\u011fer epidermal yap\u0131larda bulunur ve t\u00fcy, sa\u00e7, pen\u00e7e, gaga, toynak, boynuzun yan\u0131 s\u0131ra beynin gri maddesi, omurilik ve retina sinirlerinin bir proteinidir.<\/span><\/p>\n

X-\u0131\u015f\u0131n\u0131 k\u0131r\u0131n\u0131m analizine g\u00f6re, keratinlerin iki t\u00fcr uzaysal yap\u0131s\u0131 vard\u0131r: \u03b1-helikal yap\u0131lar (\u03b1-keratinler) ve \u03b2-katl\u0131 lamel yap\u0131lar (\u03b2-keratinler). \u0130lki y\u00fcn gibi, ikincisi ise ipek kalp proteini gibidir.<\/span>
\nKeratin daha fazla sistin i\u00e7erdi\u011finden, dis\u00fclfit ba\u011f\u0131 i\u00e7eri\u011fi son derece y\u00fcksektir ve protein peptit zinciri \u00e7apraz ba\u011flay\u0131c\u0131 bir rol oynar, bu nedenle keratinin kimyasal \u00f6zellikleri \u00f6zellikle kararl\u0131d\u0131r ve y\u00fcksek mekanik mukavemete sahiptir. Kolayca \u00e7\u00f6z\u00fcn\u00fcr ve sindirilebilir de\u011fildirler ve daha fazla sistin (14-15%) ve nitrojen i\u00e7eri\u011fi (21-24.5%) i\u00e7erirler. Ezilmi\u015f t\u00fcyler ve domuz k\u0131l\u0131, 15-20 pound buhar bas\u0131nc\u0131nda bir saat boyunca \u0131s\u0131l i\u015fleme tabi tutulur, sindirilebilirliklerini 70-80%'ye \u00e7\u0131kar\u0131r ve sistin i\u00e7eri\u011fini 5-6% azalt\u0131r.<\/span><\/p>\n

\u25baK'nin Uygulanmas\u0131<\/strong>eratin<\/strong><\/span><\/div>\n

\u2666 Yem ve F<\/strong>Ood\u00a0<\/strong>I<\/strong>end\u00fcstri<\/strong><\/span>
\nT\u00fcy keratini y\u00fcksek kaliteli yem proteini olarak kullan\u0131labilir. Keratin kullan\u0131m\u0131 ayr\u0131ca, \u00e7iftlik hayvanlar\u0131n\u0131n ve k\u00fcmes hayvanlar\u0131n\u0131n b\u00fcy\u00fcmesi i\u00e7in gerekli olan eser metal iyonlar\u0131yla reaksiyona girebilen, d\u00f6ng\u00fcsel bir yap\u0131ya sahip koordinasyon bile\u015fikleri olu\u015fturabilen ve eser elementlerin kullan\u0131m oran\u0131n\u0131 art\u0131rabilen bir amino asit eser element \u015felatlama maddesi \u00fcretebilir.<\/span><\/p>\n

T\u00fcy keratini ayr\u0131ca glutamik asit, aspartik asit ve di\u011fer taze amino asitler bak\u0131m\u0131ndan zengindir ve g\u0131da i\u015fleme end\u00fcstrisine uygulanan yeni g\u0131da katk\u0131 maddeleri \u00fcretmek i\u00e7in kullan\u0131labilir.<\/span><\/p>\n

\u2666 Eczac\u0131l\u0131k<\/strong><\/span>
\nBaz\u0131 cilt hastal\u0131klar\u0131n\u0131n mantar benzeri maddeler taraf\u0131ndan \u00fcretilen keratinazlar\u0131n cilde n\u00fcfuz etmesinden kaynakland\u0131\u011f\u0131 ve bu \u00f6zelli\u011fin mantar benzeri cilt hastal\u0131klar\u0131n\u0131n tedavisi i\u00e7in ila\u00e7lar\u0131n geli\u015ftirilmesi ve kullan\u0131lmas\u0131 i\u00e7in kullan\u0131labilece\u011fi bulunmu\u015ftur. Bile\u015fik keratin amino asit \u00e7\u00f6zeltisi, insan plazmas\u0131n\u0131n bir k\u0131sm\u0131n\u0131n yerini alarak beslenmeyi desteklemek i\u00e7in do\u011frudan insan v\u00fccuduna enjekte edilebilir.<\/span>
\nKeratindeki sistein, ya\u011fl\u0131 karaci\u011fer, siroz ve di\u011fer karaci\u011fer hastal\u0131klar\u0131n\u0131 etkili bir \u015fekilde \u00f6nleyebilen karaci\u011feri koruyucu bir etkiye sahiptir ve ayr\u0131ca mesane miyoziti, alopesi ve toksisite bozukluklar\u0131n\u0131n tedavisinde dikkate de\u011fer bir etkinli\u011fe sahiptir.<\/span><\/p>\n

\u2666 G\u00fcbreler, P<\/strong>estisitler ve\u00a0<\/strong>E<\/strong>\u00c7EVRESEL\u00a0<\/strong>P<\/strong>KORUMA<\/strong><\/span>
\n\u0130\u015flenmi\u015f t\u00fcylerin ham tozu, hayvan g\u00fcbresine daha ucuz bir alternatif olarak s\u0131v\u0131 amino asit bile\u015fimli g\u00fcbre \u00fcretmek i\u00e7in kullan\u0131labilecek yakla\u015f\u0131k 5% azot kayna\u011f\u0131 i\u00e7erir.<\/span><\/p>\n

Keratin hidrolizi ile \u00fcretilen amino asitler ve t\u00fcrevleri ile metal kompleksleri, \u00fcr\u00fcnler \u00fczerinde sterilizasyon hastal\u0131k \u00f6nleme ve b\u00fcy\u00fcme uyar\u0131m\u0131 gibi ikili etkilere sahiptir. Fungisit, insektisit, herbisit ve bitki b\u00fcy\u00fcmesini te\u015fvik edici olarak kullan\u0131labilirler. Bile\u015fik amino asitler, t\u00fcylerin hidrolize edilmesi ve organofosforlu pestisitlerdeki fosfat ba\u011f\u0131n\u0131 hidrolize ederek \u00fcr\u00fcnlerdeki pestisit kal\u0131nt\u0131lar\u0131n\u0131 azaltabilen bile\u015fik amino asitlerin kalsiyum bile\u015fiklerini \u00fcretmek i\u00e7in kalsiyum karbonat ile reaksiyona girmesiyle \u00fcretilir.<\/span><\/p>\n

Bronzla\u015fma\u00a0<\/strong>I<\/strong>end\u00fcstri<\/strong><\/span>
\nS\u0131\u011f\u0131r derisi \u00fcst derinin t\u00fcy hidroliz \u00fcr\u00fcnleri ile doldurulmas\u0131, bo\u015f derinin gerilme ve y\u0131rt\u0131lma mukavemetlerini veya boyan\u0131n emilim oran\u0131n\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde etkilemeden bo\u015f derinin yumu\u015fakl\u0131\u011f\u0131n\u0131 ve uzamas\u0131n\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rabilir.<\/span><\/p>\n

Uygun alkali bozunma i\u015fleminden sonra, t\u00fcyden elde edilen protein kar\u0131\u015f\u0131m\u0131, ayakkab\u0131 \u00fcst derisi ve giysi derisi i\u00e7in bir dolgu malzemesi olarak kullan\u0131labilir, derinin boyama \u00f6zelliklerini iyile\u015ftirir ve deriye daha iyi esneklik kazand\u0131r\u0131r. Buna ek olarak, t\u00fcy proteini krom deri i\u00e7in bir bile\u015fik maddesi olarak kullan\u0131labilir.<\/span><\/p>\n

Kozmetik\u00a0<\/strong>P<\/strong>\u00dcR\u00dcNLER<\/strong><\/span>
\nKeratin kozmetikte kullan\u0131labilir. Keratin y\u00fcksek diren\u00e7li fizikokimyasal \u00f6zelliklere ve unutulmaz biyolojik rollere sahiptir ve epidermisin normal fizyolojik i\u015flevinin s\u00fcrd\u00fcr\u00fclmesinde hayati bir rol oynar.<\/span><\/p>\n

Keratinaz, kozmetik cilt bak\u0131m \u00fcr\u00fcnlerinde aktif fakt\u00f6rlerin cilt bariyerinden ge\u00e7mesine yard\u0131mc\u0131 olmak, fazla cilt keratininden kurtulmak, derin cilt bak\u0131m\u0131n\u0131 ger\u00e7ekle\u015ftirmek ve cilt kozmetolojisinde iyi bir beklentiye sahip olan epilasyonu incelemek i\u00e7in kullan\u0131l\u0131r.<\/span><\/p>\n

https:\/\/collagensei.com\/wp-content\/uploads\/2024\/07\/Hydrolysed-Keratin-267×300.jpg<\/p>","protected":false},"excerpt":{"rendered":"

\u25baWhat is keratin? 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