<\/figure>\n\n\n\nKhi \u0111\u00e1nh gi\u00e1 vai tr\u00f2 sinh h\u1ecdc c\u1ee7a s\u1eefa non so v\u1edbi collagen, \u0111i\u1ec1u quan tr\u1ecdng l\u00e0 ph\u1ea3i ph\u00e2n bi\u1ec7t gi\u1eefa \u201cch\u1ea5t truy\u1ec1n tin\u201d v\u00e0 \u201cnguy\u00ean li\u1ec7u x\u00e2y d\u1ef1ng\u201d. S\u1eefa non l\u00e0 m\u1ed9t ch\u1ea5t l\u1ecfng ph\u1ee9c t\u1ea1p, c\u00f3 ho\u1ea1t t\u00ednh sinh h\u1ecdc, \u0111\u01b0\u1ee3c m\u1ec7nh danh l\u00e0 \u201cv\u1eafc-xin \u0111\u1ea7u ti\u00ean c\u1ee7a thi\u00ean nhi\u00ean\u201d, ch\u1ee7 y\u1ebfu ho\u1ea1t \u0111\u1ed9ng nh\u01b0 m\u1ed9t ch\u1ea5t \u0111i\u1ec1u h\u00f2a mi\u1ec5n d\u1ecbch v\u00e0 trung t\u00e2m truy\u1ec1n t\u00edn hi\u1ec7u t\u0103ng tr\u01b0\u1edfng, gi\u00fap truy\u1ec1n mi\u1ec5n d\u1ecbch th\u1ee5 \u0111\u1ed9ng v\u00e0 ph\u1ee5c h\u1ed3i ni\u00eam m\u1ea1c ru\u1ed9t th\u00f4ng qua c\u00e1c immunoglobulin v\u00e0 y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng; ng\u01b0\u1ee3c l\u1ea1i, collagen l\u00e0 m\u1ed9t lo\u1ea1i protein c\u1ea5u tr\u00fac chuy\u00ean bi\u1ec7t, \u0111\u00f3ng vai tr\u00f2 l\u00e0 th\u00e0nh ph\u1ea7n s\u1ee3i ch\u00ednh c\u1ee7a c\u00e1c m\u00f4 li\u00ean k\u1ebft trong c\u01a1 th\u1ec3, cung c\u1ea5p ma tr\u1eadn axit amin th\u00f4 c\u1ea7n thi\u1ebft \u0111\u1ec3 duy tr\u00ec t\u00ednh to\u00e0n v\u1eb9n c\u01a1 h\u1ecdc v\u00e0 \u0111\u1ed9 \u0111\u00e0n h\u1ed3i c\u1ee7a da, x\u01b0\u01a1ng v\u00e0 kh\u1edbp. Trong khi s\u1eefa non \u201ch\u01b0\u1edbng d\u1eabn\u201d h\u1ec7 th\u1ed1ng ph\u00f2ng v\u1ec7 v\u00e0 s\u1eeda ch\u1eefa c\u1ee7a c\u01a1 th\u1ec3, collagen \u201cx\u00e2y d\u1ef1ng l\u1ea1i\u201d khung x\u01b0\u01a1ng v\u1eadt l\u00fd gi\u1eef c\u01a1 th\u1ec3 l\u1ea1i v\u1edbi nhau.<\/p>\n\n\n\n
<\/span>Th\u00e0nh ph\u1ea7n ph\u00e2n t\u1eed: B\u00ean trong c\u00f3 g\u00ec?<\/span><\/h2>\n\n\n\n\u0110\u1ec3 hi\u1ec3u \u0111\u01b0\u1ee3c s\u1ef1 kh\u00e1c bi\u1ec7t v\u1ec1 ch\u1ee9c n\u0103ng gi\u1eefa s\u1eefa non v\u00e0 collagen, ch\u00fang ta c\u1ea7n xem x\u00e9t \u201cb\u1ea3n thi\u1ebft k\u1ebf\u201d ph\u00e2n t\u1eed c\u1ee7a ch\u00fang. M\u1eb7c d\u00f9 c\u1ea3 hai \u0111\u1ec1u c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb protein, nh\u01b0ng c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u1ee7a ch\u00fang \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf \u0111\u1ec3 th\u1ef1c hi\u1ec7n nh\u1eefng nhi\u1ec7m v\u1ee5 sinh h\u1ecdc ho\u00e0n to\u00e0n kh\u00e1c nhau.<\/p>\n\n\n\n
<\/span>S\u1eefa non: M\u1ed9t h\u1ed7n h\u1ee3p sinh h\u1ecdc \u0111a y\u1ebfu t\u1ed1<\/span><\/h3>\n\n\n\nS\u1eefa non kh\u00f4ng ph\u1ea3i l\u00e0 m\u1ed9t ch\u1ea5t \u0111\u01a1n l\u1ebb m\u00e0 l\u00e0 m\u1ed9t h\u1ec7 th\u1ed1ng ph\u1ee9c t\u1ea1p, l\u1ecfng, ch\u1ee9a h\u00e0ng tr\u0103m ph\u00e2n t\u1eed t\u00edn hi\u1ec7u. S\u1ee9c m\u1ea1nh ch\u00ednh c\u1ee7a n\u00f3 n\u1eb1m \u1edf c\u00e1c Immunoglobulin (IgG, IgA, IgM) \u2013 nh\u1eefng protein h\u00ecnh ch\u1eef Y mang l\u1ea1i kh\u1ea3 n\u0103ng mi\u1ec5n d\u1ecbch th\u1ee5 \u0111\u1ed9ng t\u1ee9c th\u00ec b\u1eb1ng c\u00e1ch trung h\u00f2a c\u00e1c t\u00e1c nh\u00e2n g\u00e2y b\u1ec7nh. Ngo\u00e0i kh\u00e1ng th\u1ec3, s\u1eefa non c\u00f2n ch\u1ee9a Lactoferrin (m\u1ed9t lo\u1ea1i protein \u0111a ch\u1ee9c n\u0103ng c\u00f3 \u0111\u1eb7c t\u00ednh kh\u00e1ng khu\u1ea9n) v\u00e0 c\u00e1c Y\u1ebfu t\u1ed1 T\u0103ng tr\u01b0\u1edfng nh\u01b0 IGF-1 v\u00e0 TGF-\u03b2. \u0110\u00e2y kh\u00f4ng ch\u1ec9 l\u00e0 c\u00e1c ch\u1ea5t dinh d\u01b0\u1ee1ng; ch\u00fang l\u00e0 nh\u1eefng \u201cs\u1ee9 gi\u1ea3 sinh h\u1ecdc\u201d k\u00edch ho\u1ea1t qu\u00e1 tr\u00ecnh ph\u1ee5c h\u1ed3i t\u1ebf b\u00e0o v\u00e0 \u0111i\u1ec1u h\u00f2a mi\u1ec5n d\u1ecbch tr\u00ean to\u00e0n b\u1ed9 c\u01a1 th\u1ec3.<\/p>\n\n\n\n
<\/span>Collagen: C\u1ea5u tr\u00fac xo\u1eafn ba<\/span><\/h3>\n\n\n\nNg\u01b0\u1ee3c l\u1ea1i, collagen l\u00e0 m\u1ed9t lo\u1ea1i protein c\u1ea5u tr\u00fac chuy\u00ean bi\u1ec7t, \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh b\u1edfi c\u1ea5u tr\u00fac \u201cba s\u1ee3i xo\u1eafn\u201d \u0111\u1ed9c \u0111\u00e1o. N\u00f3 \u0111\u01b0\u1ee3c \u0111\u1eb7c tr\u01b0ng b\u1edfi chu\u1ed7i l\u1eb7p l\u1ea1i g\u1ed3m ba axit amin: Glycine, Proline v\u00e0 Hydroxyproline. C\u1ea5u tr\u00fac d\u00e0y \u0111\u1eb7c, gi\u1ed1ng nh\u01b0 s\u1ee3i d\u00e2y n\u00e0y cung c\u1ea5p \u0111\u1ed9 b\u1ec1n k\u00e9o c\u1ea7n thi\u1ebft cho ma tr\u1eadn ngo\u1ea1i b\u00e0o (ECM). Khi ch\u00fang ta ti\u00eau th\u1ee5 collagen, n\u00f3 th\u01b0\u1eddng \u0111\u01b0\u1ee3c ph\u00e2n h\u1ee7y th\u00e0nh c\u00e1c peptit sinh h\u1ecdc (di-peptit v\u00e0 tri-peptit). C\u00e1c m\u1ea3nh n\u00e0y \u0111\u00f3ng vai tr\u00f2 nh\u01b0 \u201cph\u1ea7n c\u1ee9ng\u201d th\u00f4 ho\u1eb7c v\u1eadt li\u1ec7u x\u00e2y d\u1ef1ng m\u00e0 c\u00e1c t\u1ebf b\u00e0o s\u1ee3i s\u1eed d\u1ee5ng \u0111\u1ec3 t\u1ed5ng h\u1ee3p da, s\u1ee5n v\u00e0 m\u00f4 x\u01b0\u01a1ng m\u1edbi.
<\/p>\n\n\n\n
<\/span>So s\u00e1nh nhanh<\/span><\/h3>\n\n\n\nT\u00ednh n\u0103ng<\/strong><\/td>S\u1eefa non<\/strong><\/td>Collagen<\/strong><\/td><\/tr><\/thead>Danh m\u1ee5c ch\u00ednh<\/strong><\/td>| Ch\u1ea5t l\u1ecfng sinh h\u1ecdc \/ Ch\u1ea5t \u0111i\u1ec1u h\u00f2a mi\u1ec5n d\u1ecbch<\/td> | Protein c\u1ea5u tr\u00fac d\u1ea1ng s\u1ee3i<\/td><\/tr> | C\u00e1c th\u00e0nh ph\u1ea7n ch\u00ednh<\/strong><\/td>| IgG, Lactoferrin, C\u00e1c y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng<\/td> | Glycine, Proline, Hydroxyproline<\/td><\/tr> | Vai tr\u00f2 sinh h\u1ecdc<\/strong><\/td>| Truy\u1ec1n t\u00edn hi\u1ec7u & B\u1ea3o v\u1ec7 (Ph\u1ea7n m\u1ec1m)<\/td> | H\u1ed7 tr\u1ee3 & C\u1ea5u tr\u00fac (Ph\u1ea7n c\u1ee9ng)<\/td><\/tr> | T\u1eadp trung v\u00e0o ph\u00e2n t\u1eed<\/strong><\/td>| \u0110\u1ed9 ph\u1ee9c t\u1ea1p v\u00e0 ho\u1ea1t t\u00ednh sinh h\u1ecdc<\/td> | \u0110\u1ed9 b\u1ec1n k\u00e9o v\u00e0 m\u1eadt \u0111\u1ed9 axit amin<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<\/span>C\u00e1c ch\u1ee9c n\u0103ng sinh h\u1ecdc ch\u00ednh: C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/span><\/h2>\n\n\n\n\u0110\u1ec3 hi\u1ec3u r\u00f5 h\u01a1n v\u1ec1 \u1ee9ng d\u1ee5ng th\u1ef1c ti\u1ec5n c\u1ee7a s\u1eefa non so v\u1edbi collagen, ch\u00fang ta c\u1ea7n ph\u00e2n t\u00edch \u201cC\u01a1 ch\u1ebf t\u00e1c \u0111\u1ed9ng\u201d (MOA) c\u1ee5 th\u1ec3 c\u1ee7a t\u1eebng lo\u1ea1i. M\u1eb7c d\u00f9 c\u1ea3 hai \u0111\u1ec1u \u0111\u01b0\u1ee3c h\u1ea5p thu qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a, ch\u00fang l\u1ea1i \u0111i theo c\u00e1c con \u0111\u01b0\u1eddng sinh l\u00fd kh\u00e1c nhau \u0111\u1ec3 mang l\u1ea1i nh\u1eefng l\u1ee3i \u00edch s\u1ee9c kh\u1ecfe ri\u00eang bi\u1ec7t.<\/p>\n\n\n\n <\/span>S\u1eefa non: Ng\u01b0\u1eddi b\u1ea3o v\u1ec7 tr\u1ee5c ru\u1ed9t-mi\u1ec5n d\u1ecbch<\/span><\/h3>\n\n\n\nS\u1eefa non ch\u1ee7 y\u1ebfu c\u00f3 t\u00e1c d\u1ee5ng nh\u01b0 m\u1ed9t ch\u1ea5t truy\u1ec1n tin sinh h\u00f3a<\/strong> trong \u0111\u01b0\u1eddng ti\u00eau h\u00f3a. Vai tr\u00f2 quan tr\u1ecdng nh\u1ea5t c\u1ee7a n\u00f3 l\u00e0 duy tr\u00ec t\u00ednh to\u00e0n v\u1eb9n c\u1ee7a h\u00e0ng r\u00e0o ru\u1ed9t.<\/p>\n\n\n\n\n- \u0110i\u1ec1u h\u00f2a c\u00e1c li\u00ean k\u1ebft ch\u1eb7t ch\u1ebd:<\/strong> S\u1eefa non ch\u1ee9a c\u00e1c y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng (nh\u01b0 TGF-\u03b2) c\u00f3 t\u00e1c d\u1ee5ng k\u00edch th\u00edch c\u00e1c \u201ck\u1ebft n\u1ed1i ch\u1eb7t ch\u1ebd\u201d trong ni\u00eam m\u1ea1c ru\u1ed9t duy tr\u00ec tr\u1ea1ng th\u00e1i k\u00edn kh\u00edt. \u0110i\u1ec1u n\u00e0y gi\u00fap ng\u0103n ng\u1eeba t\u00ecnh tr\u1ea1ng \u201cru\u1ed9t r\u00f2 r\u1ec9\u201d \u2013 m\u1ed9t t\u00ecnh tr\u1ea1ng m\u00e0 c\u00e1c h\u1ea1t th\u1ee9c \u0103n ch\u01b0a ti\u00eau h\u00f3a v\u00e0 \u0111\u1ed9c t\u1ed1 x\u00e2m nh\u1eadp v\u00e0o m\u00e1u.<\/li>\n\n\n\n
- Gi\u00e1o d\u1ee5c v\u1ec1 h\u1ec7 mi\u1ec5n d\u1ecbch:<\/strong> Khi v\u00e0o \u0111\u01b0\u1eddng ru\u1ed9t, c\u00e1c Immunoglobulin (IgG) trong s\u1eefa non kh\u00f4ng ch\u1ec9 \u0111\u01a1n thu\u1ea7n t\u1ed3n t\u1ea1i \u1edf \u0111\u00f3; ch\u00fang li\u00ean k\u1ebft v\u1edbi c\u00e1c t\u00e1c nh\u00e2n g\u00e2y b\u1ec7nh (vi khu\u1ea9n v\u00e0 vi-r\u00fat), v\u00f4 hi\u1ec7u h\u00f3a ch\u00fang tr\u01b0\u1edbc khi ch\u00fang c\u00f3 th\u1ec3 g\u00e2y ra ph\u1ea3n \u1ee9ng vi\u00eam to\u00e0n th\u00e2n. \u0110\u00e2y ch\u00ednh l\u00e0 l\u00fd do t\u1ea1i sao s\u1eefa non \u0111\u01b0\u1ee3c coi l\u00e0 m\u1ed9t ch\u1ea5t \u0111i\u1ec1u h\u00f2a h\u1ec7 mi\u1ec5n d\u1ecbch theo c\u01a1 ch\u1ebf \u201ct\u1eeb tr\u00ean xu\u1ed1ng\u201d.<\/li>\n<\/ul>\n\n\n\n
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