{"id":4858,"date":"2025-03-20T14:44:49","date_gmt":"2025-03-20T06:44:49","guid":{"rendered":"https:\/\/collagensei.com\/?page_id=4858"},"modified":"2026-10-10T10:29:37","modified_gmt":"2026-10-10T02:29:37","slug":"5-mthf-%e7%b2%89%e6%9c%ab","status":"publish","type":"page","link":"https:\/\/collagensei.com\/zh\/vitamins-supplier\/5-mthf-powder\/","title":{"rendered":"5-MTHF \u7c89\u672b"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"4858\" class=\"elementor elementor-4858\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-38be80d e-con-full e-flex e-con e-parent\" data-id=\"38be80d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-604783d elementor-widget elementor-widget-html\" data-id=\"604783d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<style>\n.gensei-mthf-page{\n  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.g-spec-intro{max-width:780px;margin:0 0 20px;color:var(--g-muted)}\n@media(max-width:980px){.gensei-mthf-page .g-app-grid,.gensei-mthf-page .g-process{grid-template-columns:1fr 1fr}}\n@media(max-width:640px){.gensei-mthf-page .g-app-grid,.gensei-mthf-page .g-copy-grid,.gensei-mthf-page .g-process{grid-template-columns:1fr}}\n<\/style>\n\n<div class=\"gensei-mthf-page\">\n<section class=\"g-hero\">\n <div class=\"g-wrap g-hero-grid\">\n  <div>\n   <div class=\"g-eyebrow\">Active Folate Ingredient \u00b7 Bulk Powder<\/div>\n   <h1>Calcium L-5-Methyltetrahydrofolate (5-MTHF) Supplier<\/h1>\n   <p class=\"g-lead\">Calcium L-5-MTHF is an active folate ingredient for dietary supplement formulations, including prenatal multivitamins, methylated B-complex products and standalone folate supplements. Also known as L-methylfolate calcium or levomefolate calcium.<\/p>\n   <div class=\"g-actions\"><a class=\"g-btn g-btn-primary\" href=\"#mthf-inquiry\">Request a Quote<\/a><\/div>\n   <div class=\"g-facts\"><span class=\"g-fact\">CAS 151533-22-1<\/span><span class=\"g-fact\">Calcium Salt<\/span><span class=\"g-fact\">Crystalline Powder<\/span><\/div>\n  <\/div>\n  <div class=\"g-image-card\"><img decoding=\"async\" src=\"https:\/\/collagensei.com\/wp-content\/uploads\/2026\/09\/Calcium-L-5-Methyltetrahydrofolate.webp\" alt=\"Calcium L-5-Methyltetrahydrofolate powder\" loading=\"eager\" fetchpriority=\"high\"><\/div>\n <\/div>\n<\/section>\n<section class=\"g-section\">\n <div class=\"g-wrap\">\n  <div class=\"g-section-head\"><h2>Applications in Supplement Formulations<\/h2><p>Calcium L-5-MTHF provides a methylated folate source for products formulated with active B vitamins and other nutritional ingredients.<\/p><\/div>\n  <div class=\"g-app-grid\">\n   <div class=\"g-app-card\"><h3>Prenatal &amp; Maternal Nutrition<\/h3><p>For prenatal multivitamins and maternal nutrition formulas that specify L-5-MTHF as their folate source, alongside ingredients such as choline, vitamin B12 and iron.<\/p><\/div>\n   <div class=\"g-app-card\"><h3>Methylated B-Complex<\/h3><p>For B-vitamin blends combining methylfolate with methylcobalamin, vitamin B6 and riboflavin in capsules or tablets.<\/p><\/div>\n   <div class=\"g-app-card\"><h3>Standalone Folate &amp; Multivitamins<\/h3><p>For single-ingredient methylfolate supplements and multivitamin formulas that call for a defined calcium L-5-MTHF ingredient.<\/p><\/div>\n  <\/div>\n <\/div>\n<\/section>\n<section class=\"g-section g-section-soft\">\n <div class=\"g-wrap\">\n  <div class=\"g-section-head\"><h2>Calcium L-5-MTHF and Other Folate Forms<\/h2><p>The folate source affects ingredient specifications, formulation behavior and finished-product labeling.<\/p><\/div>\n  <div class=\"g-copy-grid\">\n   <div class=\"g-copy-panel\"><h3>Active Folate Instead of Folic Acid<\/h3><p>L-5-MTHF is the methylated form of folate. Calcium L-5-MTHF supplies this form as a calcium salt, rather than as synthetic folic acid.<\/p><p>It can be selected for products positioned around methylated B vitamins or folic-acid-free ingredient lists. Finished-product claims and permitted uses depend on the destination market.<\/p><\/div>\n   <div class=\"g-copy-panel\"><h3>Calcium Salt vs. Glucosamine Salt<\/h3><p>Calcium L-5-MTHF and (6S)-5-MTHF glucosamine salt are different ingredient forms. Both supply methylfolate, but their solubility and formulation characteristics differ.<\/p><p>Calcium L-5-MTHF is a practical option to evaluate for dry blends, capsules and tablets. For beverages, liquid drops or heat-processed formats, solubility and stability should be established in the actual product matrix.<\/p><\/div>\n  <\/div>\n <\/div>\n<\/section>\n<section class=\"g-section\">\n <div class=\"g-wrap\">\n  <div class=\"g-section-head\"><h2>Formulation &amp; Manufacturing<\/h2><p>Ingredient selection and manufacturing conditions influence the amount of methylfolate delivered in each finished serving.<\/p><\/div>\n  <div class=\"g-process\">\n   <div class=\"g-process-item\"><h3>Active Folate Input<\/h3><p>The calcium-salt assay and L-5-MTHF content are distinct values. Calculate ingredient input using the active L-5-MTHF content of the applicable lot and the finished-product target.<\/p><\/div>\n   <div class=\"g-process-item\"><h3>Low-Dose Blend Uniformity<\/h3><p>Folate is often added at microgram levels per serving. Controlled weighing, premixing and blend-uniformity testing help achieve consistent distribution in larger production batches.<\/p><\/div>\n   <div class=\"g-process-item\"><h3>Finished-Product Stability<\/h3><p>Packaging, moisture, processing conditions and the surrounding formula can affect folate retention. Establish the appropriate overage and shelf life through finished-product stability studies.<\/p><\/div>\n  <\/div>\n <\/div>\n<\/section>\n<section class=\"g-section g-section-soft\">\n <div class=\"g-wrap\">\n  <div class=\"g-section-head\"><h2>Specifications &amp; Batch Test Results<\/h2><p>Calcium L-5-MTHF powder is supplied with a defined specification for identity, assay, related compounds, elemental impurities and microbiological quality.<\/p><\/div>\n  <div class=\"g-batch-meta\">\n   <div><span>Reference Batch<\/span><strong>NA260603<\/strong><\/div>\n   <div><span>Manufactured<\/span><strong>June 25, 2026<\/strong><\/div>\n   <div><span>Expiry<\/span><strong>June 24, 2028<\/strong><\/div>\n   <div><span>Origin \/ Method Reference<\/span><strong>China \u00b7 USP-NF 2024<\/strong><\/div>\n  <\/div>\n  <p class=\"g-method-note\">The results below apply to the reference batch. Test methods follow USP-NF 2024 unless otherwise stated; L-5-MTHF content is calculated.<\/p>\n      <div class=\"g-spec-stack\">\n        <details class=\"g-spec-group\" open>\n          <summary>Active Ingredient &amp; Related Compounds <span>14 test items<\/span><\/summary>\n          <div class=\"g-table-wrap\">\n            <table>\n              <thead>\n                <tr>\n                  <th>Test Item<\/th>\n                  <th>Specification<\/th>\n                  <th>Batch Result<\/th>\n                <\/tr>\n              <\/thead>\n              <tbody>\n                <tr><td>Assay (Anhydrous and solvent free)<\/td><td>95.0% - 102.0%<\/td><td>98.91%<\/td><\/tr>\n                <tr><td>L-5-MTHF<\/td><td>72.0% - 87.0%<\/td><td>80.95%<\/td><\/tr>\n                <tr><td>Calcium (Anhydrous and solvent free)<\/td><td>7.0% - 8.5%<\/td><td>8.14%<\/td><\/tr>\n                <tr><td>Total Related Compounds<\/td><td>NMT 2.5%<\/td><td>0.84%<\/td><\/tr>\n                <tr><td>4-Aminobenzoylglutamic Acid<\/td><td>NMT 0.5%<\/td><td>ND<\/td><\/tr>\n                <tr><td>4a-Hydroxy-5-Methyltetrahydrofolic Acid<\/td><td>NMT 1.0%<\/td><td>0.38%<\/td><\/tr>\n                <tr><td>(6R and 6S)-Mefox<\/td><td>NMT 1.0%<\/td><td>ND<\/td><\/tr>\n                <tr><td>Tetrahydrofolic Acid<\/td><td>NMT 0.5%<\/td><td>ND<\/td><\/tr>\n                <tr><td>7,8-Dihydrofolic Acid<\/td><td>NMT 0.5%<\/td><td>ND<\/td><\/tr>\n                <tr><td>Folic Acid<\/td><td>NMT 0.5%<\/td><td>ND<\/td><\/tr>\n                <tr><td>5,10-Methylenetetrahydropteroic Acid<\/td><td>NMT 0.5%<\/td><td>ND<\/td><\/tr>\n                <tr><td>5-Methyltetrahydropteroic Acid<\/td><td>NMT 0.5%<\/td><td>0.16%<\/td><\/tr>\n                <tr><td>Dimethyltetrahydrofolic Acid<\/td><td>NMT 0.15%<\/td><td>ND<\/td><\/tr>\n                <tr><td>Enantiomeric Impurity (D-5-methyltetrahydrofolate)<\/td><td>NMT 1.0%<\/td><td>0.50%<\/td><\/tr>\n              <\/tbody>\n            <\/table>\n          <\/div>\n        <\/details>\n\n        <details class=\"g-spec-group\">\n          <summary>Physical Control <span>7 test items<\/span><\/summary>\n          <div class=\"g-table-wrap\">\n            <table>\n              <thead>\n                <tr>\n                  <th>Test Item<\/th>\n                  <th>Specification<\/th>\n                  <th>Batch Result<\/th>\n                <\/tr>\n              <\/thead>\n              <tbody>\n                <tr><td>Appearance<\/td><td>White to light yellowish crystalline powder<\/td><td>Conforms<\/td><\/tr>\n                <tr><td>Identification<\/td><td>Retention time of the principal peak should conform with standard<\/td><td>Conforms<\/td><\/tr>\n                <tr><td>Water Content<\/td><td>6.0% - 17.0%<\/td><td>10.82%<\/td><\/tr>\n                <tr><td>Particle Size<\/td><td>NLT 90% pass 80 mesh<\/td><td>Conforms<\/td><\/tr>\n                <tr><td>Bulk Density<\/td><td>NLT 0.2 g\/ml<\/td><td>0.21 g\/ml<\/td><\/tr>\n                <tr><td>Residual Solvent - Ethanol<\/td><td>NMT 5000 ppm<\/td><td>ND<\/td><\/tr>\n                <tr><td>Residual Solvent - 2-Propanol<\/td><td>NMT 5000 ppm<\/td><td>ND<\/td><\/tr>\n              <\/tbody>\n            <\/table>\n          <\/div>\n        <\/details>\n\n        <details class=\"g-spec-group\">\n          <summary>Chemical Control <span>7 test items<\/span><\/summary>\n          <div class=\"g-table-wrap\">\n            <table>\n              <thead>\n                <tr>\n                  <th>Test Item<\/th>\n                  <th>Specification<\/th>\n                  <th>Batch Result<\/th>\n                <\/tr>\n              <\/thead>\n              <tbody>\n                <tr><td>Platinum<\/td><td>NMT 10 ppm<\/td><td>Conforms<\/td><\/tr>\n                <tr><td>Boron<\/td><td>NMT 50 ppm<\/td><td>Conforms<\/td><\/tr>\n                <tr><td>Chloride<\/td><td>NMT 0.5%<\/td><td>Conforms<\/td><\/tr>\n                <tr><td>Lead (Pb)<\/td><td>NMT 1.0 ppm<\/td><td>Conforms<\/td><\/tr>\n                <tr><td>Arsenic (As)<\/td><td>NMT 1.5 ppm<\/td><td>Conforms<\/td><\/tr>\n                <tr><td>Cadmium (Cd)<\/td><td>NMT 0.5 ppm<\/td><td>Conforms<\/td><\/tr>\n                <tr><td>Mercury (Hg)<\/td><td>NMT 1.5 ppm<\/td><td>Conforms<\/td><\/tr>\n              <\/tbody>\n            <\/table>\n          <\/div>\n        <\/details>\n\n        <details class=\"g-spec-group\">\n          <summary>Microbiological Control <span>8 test items<\/span><\/summary>\n          <div class=\"g-table-wrap\">\n            <table>\n              <thead>\n                <tr>\n                  <th>Test Item<\/th>\n                  <th>Specification<\/th>\n                  <th>Batch Result<\/th>\n                <\/tr>\n              <\/thead>\n              <tbody>\n                <tr><td>Total Plate Count<\/td><td>NMT 1000 cfu\/g<\/td><td>Conforms<\/td><\/tr>\n                <tr><td>Yeast &amp; Mold<\/td><td>NMT 100 cfu\/g<\/td><td>Conforms<\/td><\/tr>\n                <tr><td>Salmonella<\/td><td>Negative<\/td><td>Negative<\/td><\/tr>\n                <tr><td>E. Coli<\/td><td>Negative<\/td><td>Negative<\/td><\/tr>\n                <tr><td>Staphylococcus Aureus<\/td><td>Negative<\/td><td>Negative<\/td><\/tr>\n                <tr><td>Pseudomonas aeruginosa<\/td><td>Negative<\/td><td>Negative<\/td><\/tr>\n                <tr><td>Candida albicans<\/td><td>Negative<\/td><td>Negative<\/td><\/tr>\n                <tr><td>Clostridia<\/td><td>Negative<\/td><td>Negative<\/td><\/tr>\n              <\/tbody>\n            <\/table>\n          <\/div>\n        <\/details>\n      <\/div>\n\n\n  <p class=\"g-table-note\">ND = Not Detected &nbsp;\u00b7&nbsp; NMT = Not More Than &nbsp;\u00b7&nbsp; NLT = Not Less Than<\/p>\n <\/div>\n<\/section>\n<section class=\"g-section\">\n <div class=\"g-wrap\">\n  <div class=\"g-section-head\"><h2>Packaging &amp; Storage<\/h2><\/div>\n  <div class=\"g-supply-grid\">\n   <div class=\"g-supply-card\"><span>Pack Size<\/span><strong>1 kg or 5 kg<\/strong><p>Vacuum-packed in two inner plastic bags and a paper carton.<\/p><\/div>\n   <div class=\"g-supply-card\"><span>Storage Conditions<\/span><strong>Cool, dry place<\/strong><p>Keep the container tightly closed.<\/p><\/div>\n   <div class=\"g-supply-card\"><span>Shelf Life<\/span><strong>2 years<\/strong><p>When sealed and stored properly.<\/p><\/div>\n  <\/div>\n <\/div>\n<\/section>\n<section class=\"g-inquiry-section\" id=\"mthf-inquiry\">\n <div class=\"g-wrap g-inquiry-grid\">\n  <div class=\"g-inquiry-copy\">\n   <div class=\"g-inquiry-pill\">Calcium L-5-MTHF Supply<\/div>\n   <h2>Discuss Your Ingredient Requirements<\/h2>\n   <p>Tell us the quantity you need, your destination market and the type of supplement you are developing. Contact GENSEI for a quotation, current availability and the relevant batch documentation.<\/p>\n  <\/div>\n  <div class=\"g-form-card\"><h3>Send Your Inquiry<\/h3><p class=\"g-form-intro\">Share your company details and project requirements.<\/p>\n<div class=\"wpcf7 no-js\" id=\"wpcf7-f74-o1\" lang=\"zh-CN\" dir=\"ltr\" data-wpcf7-id=\"74\">\n<div class=\"screen-reader-response\"><p role=\"status\" aria-live=\"polite\" aria-atomic=\"true\"><\/p> <ul><\/ul><\/div>\n<form action=\"\/zh\/wp-json\/wp\/v2\/pages\/4858#wpcf7-f74-o1\" method=\"post\" class=\"wpcf7-form init\" aria-label=\"\u7559\u8a00\u8868\u5355\" novalidate=\"novalidate\" data-status=\"init\">\n<fieldset class=\"hidden-fields-container\"><input type=\"hidden\" name=\"_wpcf7\" value=\"74\" \/><input type=\"hidden\" name=\"_wpcf7_version\" value=\"6.1.7\" \/><input type=\"hidden\" name=\"_wpcf7_locale\" value=\"zh_CN\" \/><input type=\"hidden\" name=\"_wpcf7_unit_tag\" value=\"wpcf7-f74-o1\" \/><input type=\"hidden\" 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