Riboflavin Sodium Phosphate Supplier
Bulk Riboflavin Sodium Phosphate, also referenced as Riboflavin 5âē-Phosphate Sodium, supplied with a defined analytical specification covering riboflavin assay, related substances and batch-specific quality data.
Riboflavin Sodium Phosphate Product Overview
The batch specification identifies the material through fluorescence together with reactions for sodium and phosphate.
Identity & Physical Profile
USP distinguishes an anhydrous sodium salt and a dihydrate form. This distinction matters because hydrate state changes molecular weight and should not be inferred from a product specification when the commercial specification does not state it. FCC describes the material as a fine orange-yellow crystalline powder that is hygroscopic and substantially more water-soluble than standard Riboflavin.
Phosphate Sodium Derivative
The phosphate group and sodium counterion distinguish this material chemically from standard Riboflavin.
āļĢāļđāļāđāļāļāļāļĩāđāļĨāļ°āļĨāļēāļĒāđāļāļāđāļģ
Approximately 1 g dissolves in about 30 mL of water under the FCC description.
Hygroscopic & Light-Sensitive in Solution
The material is hygroscopic, and solutions are sensitive to light exposure.
Understanding the Riboflavin Assay Basis
Assay is expressed as riboflavin content calculated on a dry basis. It should be interpreted on that defined basis rather than relabeled as generic product purity.
Riboflavin Sodium Phosphate Specification & Batch Results
Acceptance criteria and certified batch results are presented side by side for direct analytical review.
| Test Item | āļāđāļāļāļģāļŦāļāļ | Batch Result |
|---|---|---|
| Identity & Physical Properties | ||
| āļāļģāļāļāļīāļāļēāļĒ | Yellow to orange-yellow crystalline powder | āļŠāļāļāļāļĨāđāļāļāļāļąāļ |
| Fluorescence Test | Pale greenish-yellow by transmitted light; intense yellowish-green fluorescence under long-wave UV disappears upon addition of mineral acids or alkalies | āļŠāļāļāļāļĨāđāļāļāļāļąāļ |
| Sodium & Phosphate | Filtrate gives reactions of sodium and phosphate | āļŠāļāļāļāļĨāđāļāļāļāļąāļ |
| Specific Optical Rotation | +37.0° to +42.0° | +39.6° |
| pH of 1.0% Solution | 5.0â6.5 | 6.0 |
| Lumiflavin | Absorbance âĪ0.025 | 0.001 |
| Sulphated Ash | âĪ25.0% | 21.9% |
| āļāļēāļĢāļŠāļđāļāđāļŠāļĩāļĒāļāļēāļāļāļēāļĢāļāļāđāļŦāđāļ | âĪ7.5% | 5.4% |
| Related Substances | ||
| Free Riboflavin | âĪ6.0% | 4.1% |
| Riboflavin Diphosphate | âĪ6.0% | 3.1% |
| Inorganic Phosphate | âĪ1.0% | 0.23% |
| Elemental / Heavy Metal Controls | ||
| Heavy Metals (as Pb) | âĪ10 ppm | <10 ppm |
| āđāļāļāđāļĄāļĩāļĒāļĄ | âĪ1 ppm | <0.005 ppm |
| āļāļēāļĢāđāđāļāļāļīāļ | âĪ1 ppm | <0.01 ppm |
| āļŦāļąāļ§āļŦāļāđāļē | âĪ2 ppm | <0.02 ppm |
| āđāļĄāļāļĢāđāļāļīāļ§āļĢāļĩ | âĪ0.1 ppm | <0.005 ppm |
| āļāļēāļĢāļ§āļīāđāļāļĢāļēāļ°āļŦāđ | ||
| Riboflavin on Dry Basis | 73.0%â79.0% | 75.4% |
| āļŠāļēāļĢāļĨāļ°āļĨāļēāļĒāļāļĩāđāđāļŦāļĨāļ·āļ | ||
| Methanol | âĪ3000 ppm | 55 ppm |
| Acetonitrile | âĪ410 ppm | 3 ppm |
| Pyridine | âĪ200 ppm | 5 ppm |
| Microbiological Quality | ||
| Total Aerobic Microbial Count | âĪ1000 CFU/g | <100 CFU/g |
| āļĒāļĩāļŠāļāđāđāļĨāļ°āđāļāļ·āđāļāļĢāļē | âĪ100 CFU/g | <10 CFU/g |
| āļāļĩ.āđāļāđāļĨ | Absence/g | Not Detectable |
| āļāļąāļĨāđāļĄāđāļāļĨāļĨāļē | Absence/g | Not Detectable |
| Staphylococcus aureus | Absence/g | Not Detectable |
Riboflavin Sodium Phosphate Quality Evaluation
Quality evaluation extends beyond assay to related substances, residual solvents, elemental impurities and microbiological controls. Together, these parameters provide a broader analytical profile for the material.
Riboflavin Sodium Phosphate vs. Riboflavin
The distinction starts with product identity and continues through the assay basis and analytical profile.
| Selection Point | Riboflavin Sodium Phosphate | āđāļĢāđāļāļāļĨāļēāļ§āļīāļ |
|---|---|---|
| āļĢāļđāļāđāļāļāļāļēāļāđāļāļĄāļĩ | Phosphate sodium derivative | Unphosphorylated Riboflavin |
| Water behavior in established physical-property data | Water-soluble; FCC reports about 1 g in 30 mL | Very slightly soluble |
| Moisture behavior | Described by FCC as hygroscopic | No hygroscopic designation used in the cited FCC description |
| Analytical profile in batch specification | Includes related substances, residual solvents and microbiological controls | Includes a defined particle-size requirement |
| āļāļēāļĢāļāļĩāļāļ§āļēāļĄāļāļĨāļāļēāļĢāļ§āļīāđāļāļĢāļēāļ°āļŦāđ | Expressed as riboflavin content for the phosphate sodium material | Assay applies to standard Riboflavin |
Packaging, Storage & Batch Traceability
Store in a well-closed container protected from light and moisture. Batch traceability includes manufacturing, retest and packing information.
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