Riboflavin Sodium Phosphate Supplier
Bulk Riboflavin Sodium Phosphate, also referenced as Riboflavin 5′-Phosphate Sodium, supplied with a defined analytical specification covering riboflavin assay, related substances and batch-specific quality data.
Riboflavin Sodium Phosphate Product Overview
The batch specification identifies the material through fluorescence together with reactions for sodium and phosphate.
Identity & Physical Profile
USP distinguishes an anhydrous sodium salt and a dihydrate form. This distinction matters because hydrate state changes molecular weight and should not be inferred from a product specification when the commercial specification does not state it. FCC describes the material as a fine orange-yellow crystalline powder that is hygroscopic and substantially more water-soluble than standard Riboflavin.
Phosphate Sodium Derivative
The phosphate group and sodium counterion distinguish this material chemically from standard Riboflavin.
Water-Soluble Form
Approximately 1 g dissolves in about 30 mL of water under the FCC description.
Hygroscopic & Light-Sensitive in Solution
The material is hygroscopic, and solutions are sensitive to light exposure.
Understanding the Riboflavin Assay Basis
Assay is expressed as riboflavin content calculated on a dry basis. It should be interpreted on that defined basis rather than relabeled as generic product purity.
Riboflavin Sodium Phosphate Specification & Batch Results
Acceptance criteria and certified batch results are presented side by side for direct analytical review.
| Test Item | 規格 | Batch Result |
|---|---|---|
| Identity & Physical Properties | ||
| 說明 | Yellow to orange-yellow crystalline powder | 符合 |
| Fluorescence Test | Pale greenish-yellow by transmitted light; intense yellowish-green fluorescence under long-wave UV disappears upon addition of mineral acids or alkalies | 符合 |
| Sodium & Phosphate | Filtrate gives reactions of sodium and phosphate | 符合 |
| Specific Optical Rotation | +37.0° to +42.0° | +39.6° |
| pH of 1.0% Solution | 5.0–6.5 | 6.0 |
| Lumiflavin | Absorbance ≤0.025 | 0.001 |
| Sulphated Ash | ≤25.0% | 21.9% |
| 乾燥損失 | ≤7.5% | 5.4% |
| Related Substances | ||
| Free Riboflavin | ≤6.0% | 4.1% |
| Riboflavin Diphosphate | ≤6.0% | 3.1% |
| Inorganic Phosphate | ≤1.0% | 0.23% |
| Elemental / Heavy Metal Controls | ||
| Heavy Metals (as Pb) | ≤10 ppm | <10 ppm |
| 鎘 | ≤1 ppm | <0.005 ppm |
| 砷 | ≤1 ppm | <0.01 ppm |
| 鉛 | ≤2 ppm | <0.02 ppm |
| 水銀 | ≤0.1 ppm | <0.005 ppm |
| 分析法 | ||
| Riboflavin on Dry Basis | 73.0%–79.0% | 75.4% |
| 殘留溶劑 | ||
| Methanol | ≤3000 ppm | 55 ppm |
| Acetonitrile | ≤410 ppm | 3 ppm |
| Pyridine | ≤200 ppm | 5 ppm |
| Microbiological Quality | ||
| Total Aerobic Microbial Count | ≤1000 CFU/g | <100 CFU/g |
| 酵母與黴菌 | ≤100 CFU/g | <10 CFU/g |
| 大腸桿菌 | Absence/g | Not Detectable |
| 沙門氏菌 | Absence/g | Not Detectable |
| 金黃色葡萄球菌 | Absence/g | Not Detectable |
Riboflavin Sodium Phosphate Quality Evaluation
Quality evaluation extends beyond assay to related substances, residual solvents, elemental impurities and microbiological controls. Together, these parameters provide a broader analytical profile for the material.
Riboflavin Sodium Phosphate vs. Riboflavin
The distinction starts with product identity and continues through the assay basis and analytical profile.
| Selection Point | Riboflavin Sodium Phosphate | 核黃素 |
|---|---|---|
| 化學形態 | Phosphate sodium derivative | Unphosphorylated Riboflavin |
| Water behavior in established physical-property data | Water-soluble; FCC reports about 1 g in 30 mL | Very slightly soluble |
| Moisture behavior | Described by FCC as hygroscopic | No hygroscopic designation used in the cited FCC description |
| Analytical profile in batch specification | Includes related substances, residual solvents and microbiological controls | Includes a defined particle-size requirement |
| 檢驗結果的解讀 | Expressed as riboflavin content for the phosphate sodium material | Assay applies to standard Riboflavin |
Packaging, Storage & Batch Traceability
Store in a well-closed container protected from light and moisture. Batch traceability includes manufacturing, retest and packing information.
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