Riboflavina 5′-fosfato de sódio

Riboflavin Sodium Phosphate Supplier

Bulk Riboflavin Sodium Phosphate, also referenced as Riboflavin 5′-Phosphate Sodium, supplied with a defined analytical specification covering riboflavin assay, related substances and batch-specific quality data.

Riboflavin Sodium Phosphate Product Overview

The batch specification identifies the material through fluorescence together with reactions for sodium and phosphate.

Número CAS130-40-5
AparênciaYellow to Orange-Yellow Crystalline Powder
Compendial ReferenceUSP2024

Identity & Physical Profile

USP distinguishes an anhydrous sodium salt and a dihydrate form. This distinction matters because hydrate state changes molecular weight and should not be inferred from a product specification when the commercial specification does not state it. FCC describes the material as a fine orange-yellow crystalline powder that is hygroscopic and substantially more water-soluble than standard Riboflavin.

Compendial Identity

Phosphate Sodium Derivative

The phosphate group and sodium counterion distinguish this material chemically from standard Riboflavin.

Physical Behavior

Forma solúvel em água

Approximately 1 g dissolves in about 30 mL of water under the FCC description.

Handling Context

Hygroscopic & Light-Sensitive in Solution

The material is hygroscopic, and solutions are sensitive to light exposure.

Understanding the Riboflavin Assay Basis

Assay is expressed as riboflavin content calculated on a dry basis. It should be interpreted on that defined basis rather than relabeled as generic product purity.

Riboflavin Sodium Phosphate Specification & Batch Results

Acceptance criteria and certified batch results are presented side by side for direct analytical review.

Test ItemEspecificaçãoBatch Result
Identity & Physical Properties
DescriçãoYellow to orange-yellow crystalline powderEm conformidade com
Fluorescence TestPale greenish-yellow by transmitted light; intense yellowish-green fluorescence under long-wave UV disappears upon addition of mineral acids or alkaliesEm conformidade com
Sodium & PhosphateFiltrate gives reactions of sodium and phosphateEm conformidade com
Specific Optical Rotation+37.0° to +42.0°+39.6°
pH of 1.0% Solution5.0–6.56.0
LumiflavinAbsorbance ≤0.0250.001
Sulphated Ash≤25.0%21.9%
Perda na secagem≤7.5%5.4%
Related Substances
Free Riboflavin≤6.0%4.1%
Riboflavin Diphosphate≤6.0%3.1%
Inorganic Phosphate≤1.0%0.23%
Elemental / Heavy Metal Controls
Heavy Metals (as Pb)≤10 ppm<10 ppm
Cádmio≤1 ppm<0.005 ppm
Arsénico≤1 ppm<0.01 ppm
Chumbo≤2 ppm<0.02 ppm
Mercury≤0,1 ppm<0.005 ppm
Ensaio
Riboflavin on Dry Basis73.0%–79.0%75.4%
Solventes residuais
Methanol≤3000 ppm55 ppm
Acetonitrile≤410 ppm3 ppm
Pyridine≤200 ppm5 ppm
Microbiological Quality
Total Aerobic Microbial Count≤1000 CFU/g<100 CFU/g
Leveduras e bolores≤100 UFC/g<10 CFU/g
E. coliAbsence/gNot Detectable
SalmonelaAbsence/gNot Detectable
Staphylococcus aureusAbsence/gNot Detectable

Riboflavin Sodium Phosphate Quality Evaluation

Quality evaluation extends beyond assay to related substances, residual solvents, elemental impurities and microbiological controls. Together, these parameters provide a broader analytical profile for the material.

Confirm the Exact Material FormConfirm hydrate state before assigning a hydrate-specific molecular weight.
Keep Assay and Purity Terminology SeparateInterpret assay as riboflavin content on the stated dry basis rather than as generic product purity.
Review Related Substances IndividuallyReview riboflavin-related and phosphate-related components as separate analytical controls.
Check Storage Against Physical BehaviorProtect the material from moisture and limit light exposure after dissolution.

Riboflavin Sodium Phosphate vs. Riboflavin

The distinction starts with product identity and continues through the assay basis and analytical profile.

Selection PointRiboflavin Sodium PhosphateRiboflavina
Forma químicaPhosphate sodium derivativeUnphosphorylated Riboflavin
Water behavior in established physical-property dataWater-soluble; FCC reports about 1 g in 30 mLVery slightly soluble
Moisture behaviorDescribed by FCC as hygroscopicNo hygroscopic designation used in the cited FCC description
Analytical profile in batch specificationIncludes related substances, residual solvents and microbiological controlsIncludes a defined particle-size requirement
Interpretação dos resultadosExpressed as riboflavin content for the phosphate sodium materialAssay applies to standard Riboflavin

Packaging, Storage & Batch Traceability

Store in a well-closed container protected from light and moisture. Batch traceability includes manufacturing, retest and packing information.

Batch NumberC312510801
Quantidade500 kg
Packing25 kg / Drum
Manufacturing DateOct. 09, 2025
Report DateNov. 26, 2025
Retest DateOct. 09, 2028
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