Calcium L-5-Methyltetrahydrofolate (5-MTHF) Supplier
Calcium L-5-MTHF is an active folate ingredient for dietary supplement formulations, including prenatal multivitamins, methylated B-complex products and standalone folate supplements. Also known as L-methylfolate calcium or levomefolate calcium.
Applications in Supplement Formulations
Calcium L-5-MTHF provides a methylated folate source for products formulated with active B vitamins and other nutritional ingredients.
Prenatal & Maternal Nutrition
For prenatal multivitamins and maternal nutrition formulas that specify L-5-MTHF as their folate source, alongside ingredients such as choline, vitamin B12 and iron.
Methylated B-Complex
For B-vitamin blends combining methylfolate with methylcobalamin, vitamin B6 and riboflavin in capsules or tablets.
Standalone Folate & Multivitamins
For single-ingredient methylfolate supplements and multivitamin formulas that call for a defined calcium L-5-MTHF ingredient.
Calcium L-5-MTHF and Other Folate Forms
The folate source affects ingredient specifications, formulation behavior and finished-product labeling.
Active Folate Instead of Folic Acid
L-5-MTHF is the methylated form of folate. Calcium L-5-MTHF supplies this form as a calcium salt, rather than as synthetic folic acid.
It can be selected for products positioned around methylated B vitamins or folic-acid-free ingredient lists. Finished-product claims and permitted uses depend on the destination market.
Calcium Salt vs. Glucosamine Salt
Calcium L-5-MTHF and (6S)-5-MTHF glucosamine salt are different ingredient forms. Both supply methylfolate, but their solubility and formulation characteristics differ.
Calcium L-5-MTHF is a practical option to evaluate for dry blends, capsules and tablets. For beverages, liquid drops or heat-processed formats, solubility and stability should be established in the actual product matrix.
Formulation & Manufacturing
Ingredient selection and manufacturing conditions influence the amount of methylfolate delivered in each finished serving.
Active Folate Input
The calcium-salt assay and L-5-MTHF content are distinct values. Calculate ingredient input using the active L-5-MTHF content of the applicable lot and the finished-product target.
Low-Dose Blend Uniformity
Folate is often added at microgram levels per serving. Controlled weighing, premixing and blend-uniformity testing help achieve consistent distribution in larger production batches.
Finished-Product Stability
Packaging, moisture, processing conditions and the surrounding formula can affect folate retention. Establish the appropriate overage and shelf life through finished-product stability studies.
Specifications & Batch Test Results
Calcium L-5-MTHF powder is supplied with a defined specification for identity, assay, related compounds, elemental impurities and microbiological quality.
The results below apply to the reference batch. Test methods follow USP-NF 2024 unless otherwise stated; L-5-MTHF content is calculated.
Active Ingredient & Related Compounds 14 test items
| Test Item | 規格 | Batch Result |
|---|---|---|
| Assay (Anhydrous and solvent free) | 95.0% - 102.0% | 98.91% |
| L-5-MTHF | 72.0% - 87.0% | 80.95% |
| Calcium (Anhydrous and solvent free) | 7.0% - 8.5% | 8.14% |
| Total Related Compounds | NMT 2.5% | 0.84% |
| 4-Aminobenzoylglutamic Acid | NMT 0.5% | ND |
| 4a-Hydroxy-5-Methyltetrahydrofolic Acid | NMT 1.0% | 0.38% |
| (6R and 6S)-Mefox | NMT 1.0% | ND |
| Tetrahydrofolic Acid | NMT 0.5% | ND |
| 7,8-Dihydrofolic Acid | NMT 0.5% | ND |
| 葉酸 | NMT 0.5% | ND |
| 5,10-Methylenetetrahydropteroic Acid | NMT 0.5% | ND |
| 5-Methyltetrahydropteroic Acid | NMT 0.5% | 0.16% |
| Dimethyltetrahydrofolic Acid | NMT 0.15% | ND |
| Enantiomeric Impurity (D-5-methyltetrahydrofolate) | NMT 1.0% | 0.50% |
Physical Control 7 test items
| Test Item | 規格 | Batch Result |
|---|---|---|
| 外觀 | White to light yellowish crystalline powder | 符合 |
| 識別 | Retention time of the principal peak should conform with standard | 符合 |
| 含水量 | 6.0% - 17.0% | 10.82% |
| 顆粒尺寸 | NLT 90% pass 80 mesh | 符合 |
| 體積密度 | NLT 0.2 g/ml | 0.21 g/ml |
| Residual Solvent - Ethanol | NMT 5000 ppm | ND |
| Residual Solvent - 2-Propanol | NMT 5000 ppm | ND |
Chemical Control 7 test items
| Test Item | 規格 | Batch Result |
|---|---|---|
| Platinum | NMT 10 ppm | 符合 |
| 硼 | NMT 50 ppm | 符合 |
| 氯化物 | NMT 0.5% | 符合 |
| 鉛 (Pb) | NMT 1.0 ppm | 符合 |
| 砷（As） | NMT 1.5 ppm | 符合 |
| 鎘 (Cd) | NMT 0.5 ppm | 符合 |
| 汞 (Hg) | NMT 1.5 ppm | 符合 |
Microbiological Control 8 test items
| Test Item | 規格 | Batch Result |
|---|---|---|
| Total Plate Count | NMT 1000 cfu/g | 符合 |
| 酵母與黴菌 | NMT 100 cfu/g | 符合 |
| 沙門氏菌 | 否 | 否 |
| E. Coli | 否 | 否 |
| Staphylococcus Aureus | 否 | 否 |
| Pseudomonas aeruginosa | 否 | 否 |
| Candida albicans | 否 | 否 |
| Clostridia | 否 | 否 |
ND = Not Detected · NMT = Not More Than · NLT = Not Less Than
Packaging & Storage
Vacuum-packed in two inner plastic bags and a paper carton.
Keep the container tightly closed.
When sealed and stored properly.
Discuss Your Ingredient Requirements
Tell us the quantity you need, your destination market and the type of supplement you are developing. Contact GENSEI for a quotation, current availability and the relevant batch documentation.
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