Bulk 5-MTHF L-Methylfolate Calcium Powder
Calcium L-5-Methyltetrahydrofolate is the calcium salt form of 5-MTHF used in dietary supplements and nutritional formulations. Gensei supplies the ingredient for commercial purchasing with lot-specific product documentation.
5-MTHF Applications in Nutritional Formulas
L-Methylfolate Calcium provides 5-MTHF for prenatal, B-complex, multivitamin and standalone folate formulations that specify a methylated folate source.
Prenatal & Maternal Nutrition
For prenatal multivitamins and maternal nutrition formulas that specify L-5-MTHF as their folate source, alongside ingredients such as choline, vitamin B12 and iron.
Methylated B-Complex
For B-vitamin blends combining methylfolate with methylcobalamin, vitamin B6 and riboflavin in capsules or tablets.
Standalone Folate & Multivitamins
For single-ingredient methylfolate supplements and multivitamin formulas that call for a defined calcium L-5-MTHF ingredient.
L-Methylfolate Calcium and Other Folate Forms
Calcium L-5-MTHF is a specific methylfolate ingredient form and should not be treated as interchangeable with folic acid or other 5-MTHF salts.
5-MTHF Is Distinct from Folic Acid
L-5-MTHF is the methylated form of folate. Calcium L-5-MTHF supplies this form as a calcium salt, rather than as synthetic folic acid.
It can be selected for products positioned around methylated B vitamins or folic-acid-free ingredient lists. Finished-product claims and permitted uses depend on the destination market.
Calcium Salt vs. Glucosamine Salt
Calcium L-5-MTHF and (6S)-5-MTHF glucosamine salt are different ingredient forms. Both supply methylfolate, but their solubility and formulation characteristics differ.
Calcium L-5-MTHF is a practical option to evaluate for dry blends, capsules and tablets. For beverages, liquid drops or heat-processed formats, solubility and stability should be established in the actual product matrix.
Working with 5-MTHF Powder
Formulation work should account for active L-5-MTHF content, low-dose blend uniformity and finished-product stability.
Active Folate Input
The calcium-salt assay and L-5-MTHF content are distinct values. Calculate ingredient input using the active L-5-MTHF content of the applicable lot and the finished-product target.
Low-Dose Blend Uniformity
Folate is often added at microgram levels per serving. Controlled weighing, premixing and blend-uniformity testing help achieve consistent distribution in larger production batches.
Finished-Product Stability
Packaging, moisture, processing conditions and the surrounding formula can affect folate retention. Establish the appropriate overage and shelf life through finished-product stability studies.
L-Methylfolate Calcium Specification & Batch Results
The specification covers identity, active content, related compounds, physical properties, elemental limits, residual solvents and microbiological quality.
The results below apply to the reference batch. Test methods follow USP-NF 2024 unless otherwise stated; L-5-MTHF content is calculated.
Active Ingredient & Related Compounds 14 test items
| Test Item | 仕様 | Batch Result |
|---|---|---|
| Assay (Anhydrous and solvent free) | 95.0% - 102.0% | 98.91% |
| L-5-MTHF | 72.0% - 87.0% | 80.95% |
| Calcium (Anhydrous and solvent free) | 7.0% - 8.5% | 8.14% |
| Total Related Compounds | NMT 2.5% | 0.84% |
| 4-Aminobenzoylglutamic Acid | NMT 0.5% | ND |
| 4a-Hydroxy-5-Methyltetrahydrofolic Acid | NMT 1.0% | 0.38% |
| (6R and 6S)-Mefox | NMT 1.0% | ND |
| Tetrahydrofolic Acid | NMT 0.5% | ND |
| 7,8-Dihydrofolic Acid | NMT 0.5% | ND |
| 葉酸 | NMT 0.5% | ND |
| 5,10-Methylenetetrahydropteroic Acid | NMT 0.5% | ND |
| 5-Methyltetrahydropteroic Acid | NMT 0.5% | 0.16% |
| Dimethyltetrahydrofolic Acid | NMT 0.15% | ND |
| Enantiomeric Impurity (D-5-methyltetrahydrofolate) | NMT 1.0% | 0.50% |
Physical Control 7 test items
| Test Item | 仕様 | Batch Result |
|---|---|---|
| 外観 | White to light yellowish crystalline powder | 準拠しています |
| 識別 | Retention time of the principal peak should conform with standard | 準拠しています |
| 水分 | 6.0% - 17.0% | 10.82% |
| 粒子径 | NLT 90% pass 80 mesh | 準拠しています |
| かさ密度 | NLT 0.2 g/ml | 0.21 g/ml |
| Residual Solvent - Ethanol | NMT 5000 ppm | ND |
| Residual Solvent - 2-Propanol | NMT 5000 ppm | ND |
Chemical Control 7 test items
| Test Item | 仕様 | Batch Result |
|---|---|---|
| Platinum | NMT 10 ppm | 準拠しています |
| ホウ素 | NMT 50 ppm | 準拠しています |
| Chloride | NMT 0.5% | 準拠しています |
| Lead (Pb) | NMT 1.0 ppm | 準拠しています |
| Arsenic (As) | NMT 1.5 ppm | 準拠しています |
| Cadmium (Cd) | NMT 0.5 ppm | 準拠しています |
| 水銀（Hg） | NMT 1.5 ppm | 準拠しています |
Microbiological Control 8 test items
| Test Item | 仕様 | Batch Result |
|---|---|---|
| Total Plate Count | NMT 1000 cfu/g | 準拠しています |
| 酵母とカビ | NMT 100 cfu/g | 準拠しています |
| サルモネラ菌 | 否定 | 否定 |
| E. Coli | 否定 | 否定 |
| Staphylococcus Aureus | 否定 | 否定 |
| Pseudomonas aeruginosa | 否定 | 否定 |
| Candida albicans | 否定 | 否定 |
| Clostridia | 否定 | 否定 |
ND = Not Detected · NMT = Not More Than · NLT = Not Less Than
Bulk L-Methylfolate Calcium Supply
Gensei supplies 5-MTHF / L-Methylfolate Calcium powder in the documented pack sizes for commercial ingredient purchasing.
Vacuum-packed in two inner plastic bags and a paper carton.
Keep the container tightly closed.
When sealed and stored properly.
Request Bulk L-Methylfolate Calcium Pricing
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