5-MTHF Powder (L-Methylfolate Calcium)
5-MTHF powder supplied as Calcium L-5-Methyltetrahydrofolate (L-Methylfolate Calcium) for dietary supplement formulation and bulk ingredient sourcing. The current COA identifies CAS 151533-22-1 and a USP-NF 2024 reference, with lot-specific assay, L-5-MTHF content and calcium results available for technical review.
5-MTHF Supplement & Formulation Applications
L-Methylfolate Calcium provides 5-MTHF for formulations that specify a methylated folate source. These application examples are intended for formulation planning rather than finished-product efficacy claims.
Prenatal & Maternal Nutrition
For prenatal multivitamins and maternal nutrition formulas that specify L-5-MTHF as their folate source, alongside ingredients such as choline, vitamin B12 and iron.
Methylated B-Complex
For B-vitamin blends combining methylfolate with methylcobalamin, vitamin B6 and riboflavin in capsules or tablets.
Standalone Folate & Multivitamins
For single-ingredient methylfolate supplements and multivitamin formulas that call for a defined calcium L-5-MTHF ingredient.
5-MTHF, L-Methylfolate Calcium & Other Folate Forms
The folate source affects ingredient specifications, formulation behavior and finished-product labeling.
5-MTHF Is Distinct from Folic Acid
L-5-MTHF is the methylated form of folate. Calcium L-5-MTHF supplies this form as a calcium salt, rather than as synthetic folic acid.
It can be selected for products positioned around methylated B vitamins or folic-acid-free ingredient lists. Finished-product claims and permitted uses depend on the destination market.
Calcium Salt vs. Glucosamine Salt
Calcium L-5-MTHF and (6S)-5-MTHF glucosamine salt are different ingredient forms. Both supply methylfolate, but their solubility and formulation characteristics differ.
Calcium L-5-MTHF is a practical option to evaluate for dry blends, capsules and tablets. For beverages, liquid drops or heat-processed formats, solubility and stability should be established in the actual product matrix.
Formulation & Manufacturing
Ingredient selection and manufacturing conditions influence the amount of methylfolate delivered in each finished serving.
Active Folate Input
The calcium-salt assay and L-5-MTHF content are distinct values. Calculate ingredient input using the active L-5-MTHF content of the applicable lot and the finished-product target.
Low-Dose Blend Uniformity
Folate is often added at microgram levels per serving. Controlled weighing, premixing and blend-uniformity testing help achieve consistent distribution in larger production batches.
Finished-Product Stability
Packaging, moisture, processing conditions and the surrounding formula can affect folate retention. Establish the appropriate overage and shelf life through finished-product stability studies.
Specifications & Batch Test Results
Calcium L-5-MTHF powder is supplied with a defined specification for identity, assay, related compounds, elemental impurities and microbiological quality.
The results below apply to the reference batch. Test methods follow USP-NF 2024 unless otherwise stated; L-5-MTHF content is calculated.
Active Ingredient & Related Compounds 14 test items
| Test Item | Especificação | Batch Result |
|---|---|---|
| Assay (Anhydrous and solvent free) | 95.0% - 102.0% | 98.91% |
| L-5-MTHF | 72.0% - 87.0% | 80.95% |
| Calcium (Anhydrous and solvent free) | 7.0% - 8.5% | 8.14% |
| Total Related Compounds | NMT 2.5% | 0.84% |
| 4-Aminobenzoylglutamic Acid | NMT 0.5% | ND |
| 4a-Hydroxy-5-Methyltetrahydrofolic Acid | NMT 1.0% | 0.38% |
| (6R and 6S)-Mefox | NMT 1.0% | ND |
| Tetrahydrofolic Acid | NMT 0.5% | ND |
| 7,8-Dihydrofolic Acid | NMT 0.5% | ND |
| Ácido fólico | NMT 0.5% | ND |
| 5,10-Methylenetetrahydropteroic Acid | NMT 0.5% | ND |
| 5-Methyltetrahydropteroic Acid | NMT 0.5% | 0.16% |
| Dimethyltetrahydrofolic Acid | NMT 0.15% | ND |
| Enantiomeric Impurity (D-5-methyltetrahydrofolate) | NMT 1.0% | 0.50% |
Physical Control 7 test items
| Test Item | Especificação | Batch Result |
|---|---|---|
| Aparência | White to light yellowish crystalline powder | Em conformidade com |
| Identificação | Retention time of the principal peak should conform with standard | Em conformidade com |
| Teor de água | 6.0% - 17.0% | 10.82% |
| Tamanho das partículas | NLT 90% pass 80 mesh | Em conformidade com |
| Densidade a granel | NLT 0.2 g/ml | 0.21 g/ml |
| Residual Solvent - Ethanol | NMT 5000 ppm | ND |
| Residual Solvent - 2-Propanol | NMT 5000 ppm | ND |
Chemical Control 7 test items
| Test Item | Especificação | Batch Result |
|---|---|---|
| Platinum | NMT 10 ppm | Em conformidade com |
| Boron | NMT 50 ppm | Em conformidade com |
| Chloride | NMT 0.5% | Em conformidade com |
| Chumbo (Pb) | NMT 1.0 ppm | Em conformidade com |
| Arsénio (As) | NMT 1.5 ppm | Em conformidade com |
| Cádmio (Cd) | NMT 0.5 ppm | Em conformidade com |
| Mercúrio (Hg) | NMT 1.5 ppm | Em conformidade com |
Microbiological Control 8 test items
| Test Item | Especificação | Batch Result |
|---|---|---|
| Total Plate Count | NMT 1000 cfu/g | Em conformidade com |
| Leveduras e bolores | NMT 100 cfu/g | Em conformidade com |
| Salmonela | Negativo | Negativo |
| E. Coli | Negativo | Negativo |
| Staphylococcus Aureus | Negativo | Negativo |
| Pseudomonas aeruginosa | Negativo | Negativo |
| Candida albicans | Negativo | Negativo |
| Clostridia | Negativo | Negativo |
ND = Not Detected · NMT = Not More Than · NLT = Not Less Than
Packaging & Storage
Vacuum-packed in two inner plastic bags and a paper carton.
Keep the container tightly closed.
When sealed and stored properly.
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